Functional Polymorphisms in the TERT Promoter Are Associated with Risk of Serous Epithelial Ovarian and Breast Cancers
نویسندگان
چکیده
Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity.
منابع مشابه
Functional polymorphisms in the TERT promoter are associated with risk of serious ovarian and breast cancer
Functional polymorphisms in the TERT promoter are associated with risk of serious ovarian and breast cancer Jonathan Beesley, Hilda Pickett, Sharon Johnatty, Xiaoqing Chen, Jun Jun Li, David Rider, Michael Stutz, Diether Lambrecht, Jenny Chang-Claude, Thilo Dork, Marc Goodman, Bart Kiemmney, Elisa Bandera, Linda Kelemen, Shan Wang-Gorke, Ian Campbell, Simon Gayther, Susan Ramus, Ellen Goode, Ro...
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